Protein Details: β2 (Calcium-activated potassium channel subunit beta-2)

Protein ID

ICDB_Pro_1189

Protein Name

β2 (Calcium-activated potassium channel subunit beta-2)

Gene Name

Kcnmb2

Organism

Rattus norvegicus (Rat)

Length

235 amino acids

AlphaFoldDB

AF-Q811Q0-F1-model_v4.pdb

Function

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1; thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex (By similarity)

Sequence

MFIWTSGRTSSSYRHDEKRNIYQKIRDHDLLDKRKTVTALKAGEDRAILLGLAMMVCSIMMYFLLGITLLRSYMQSVWTEEAQRALLNVSITETFNCSFSCGPDCWKLSQYPCLQVYVNLTSSGEKLLLYHTEETMKINQKCSYIPKCGNNFEESMSLVSVVMENFRRHQHFPCYSDPEGNQKSVILTKLYSSNVLFHSLFWPTCMMAGGVAIVAMVKLTQYLSLLCERIQRINR

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Highly expressed in brain and heart. Also expressed in lung.

DOI ID

10.1002/cne.10471; 10.1523/jneurosci.19-13-05255.1999

RefSeq

NP_789831.1